You and your doctor should talk about vardenafil hydrochloride orally disintegrating tablets when you start taking it and at regular checkups. If you do not understand the information, or have questions, talk with your doctor or pharmacist.WHAT IMPORTANT INFORMATION SHOULD YOU KNOW ABOUT VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Vardenafil hydrochloride orally disintegrating tablets are not interchangeable with vardenafil film-coated tablets (LEVITRA).Vardenafil hydrochloride orally disintegrating tablets can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines.
Frequently asked questions
With a sudden drop in blood pressure, you could get dizzy, faint, or have a heart attack or stroke.Vardenafil hydrochloride orally disintegrating tablets contain phenylalanine which can be harmful to people who have phenylketonuria. Talk to your doctor if you have phenylketonuria.Do not take vardenafil hydrochloride orally disintegrating tablets if you:· Take any medicines called “nitrates” (often used to control chest pain, also known as angina)· Use recreational drugs called “poppers” like amyl nitrate and butyl nitrate.· Take riociguat (Adempas®), a guanulate cyclase stimulator, a medicine that treats pulmonary arterial hypertension and chronic-thromboembolic pulmonary hypertension. (See “Who Should Not Take Vardenafil Hydrochloride Orally Disintegrating Tablets?”)Tell all your healthcare providers that you take vardenafil hydrochloride orally disintegrating tablets. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took vardenafil hydrochloride orally disintegrating tablets.WHAT ARE VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Vardenafil hydrochloride orally disintegrating tablets are a prescription medicine taken by mouth for the treatment of erectile dysfunction (ED) in men.ED is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. A man who has trouble getting or keeping an erection should see his doctor for help if the condition bothers him. Vardenafil hydrochloride orally disintegrating tablets may help a man with ED get and keep an erection when he is sexually excited.Vardenafil hydrochloride orally disintegrating tablets does not:· Cure ED.· Increase a man’s sexual desire.· Protect a man or his partner from sexually transmitted diseases, including HIV. Speak to your doctor about ways to guard against sexually transmitted diseases.· Serve as a male form of birth control.Vardenafil hydrochloride orally disintegrating tablets are only for men with ED. Vardenafil hydrochloride orally disintegrating tablets are not for women or children. Vardenafil hydrochloride orally disintegrating tablets must be used only under a doctor’s care.HOW DOES VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS WORK?When a man is sexually stimulated, his body’s normal physical response is to increase blood flow to his penis.
| Dosage (mg) | Typical Usage | Onset of Action | Duration of Effect |
|---|---|---|---|
| 10 | Mild to moderate ED | 30-60 minutes | Up to 4 hours |
| 20 | Moderate to severe ED | 30-60 minutes | Up to 4-5 hours |
| 5 | Lower dose for less side effects | 30-60 minutes | Up to 4 hours |
| 25 | Off-label use, clinical trials | 30-60 minutes | Up to 4 hours |
Vardenafil hydrochloride orally disintegrating tablets helps increase blood flow to the penis and may help men with ED get and keep an erection satisfactory for sexual activity. Once a man has completed sexual activity, blood flow to his penis decreases, and his erection goes away.WHO CAN TAKE VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Talk to your doctor to decide if vardenafil hydrochloride orally disintegrating tablets are right for you.Vardenafil hydrochloride orally disintegrating tablets have been shown to be effective in men over the age of 18 years who have erectile dysfunction, including men with diabetes.WHO SHOULD NOT TAKE VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Do not take vardenafil hydrochloride orally disintegrating tablets if you:· Take any medicines called “nitrates” (see “What important information should you know about vardenafil hydrochloride orally disintegrating tablets?”). Nitrates are commonly used to treat angina.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Generic | 10mg | 270 + 10 Pills | 308.71€ 294.01€ | |
| Kamagra Soft Tabs | 100 mg | 84 + 4 Pills | 233.05€ 221.95€ | |
| Levitra Professional | 20mg | 60 + 2 Pills | 223.11€ 212.49€ | |
| Viagra Generic | 150mg | 120 + 8 Pills | 177.58€ 169.12€ | |
| Kamagra Polo | 100 mg | 12 Pills | 60.21€ 57.34€ | |
| Levitra Professional | 20mg | 180 + 4 Pills | 502.31€ 478.39€ | |
| Viagra Generic | 25mg | 180 + 6 Pills | 154.93€ 147.55€ | |
| Viagra Oral Jelly | 100mg | 63 + 7 Sachets | 190.54€ 181.47€ | |
| Cialis Generic | 40mg | 30 + 4 Pills | 74.97€ 71.40€ | |
| Viagra Super Active | 100mg | 270 + 30 Pills | 390.61€ 372.01€ | |
| Viagra Generic | 100mg | 120 + 6 Pills | 149.50€ 142.38€ | |
| Viagra Original | 100mg | 64 + 4 Pills | 264.15€ 251.57€ | |
| Cialis Generic | 40mg | 180 + 10 Pills | 277.29€ 264.09€ | |
| Viagra Soft Tabs | 100mg | 270 + 10 Pills | 419.95€ 399.95€ |
Angina is a symptom of heart disease and can cause pain in your chest, jaw, or down your arm.Medicines called nitrates include nitroglycerin that is found in tablets, sprays, ointments, pastes, or patches. Nitrates can also be found in other medicines such as isosorbide dinitrate or isosorbide mononitrate. Some recreational drugs called “poppers” also contain nitrates, such as amyl nitrate and butyl nitrate. Do not use vardenafil hydrochloride orally disintegrating tablets if you are using these drugs. Ask your doctor or pharmacist if you are not sure if any of your medicines are nitrates.· Take riociguat, a guanylate cyclase stimulator, a medicine that treats pulmonary arterial hypertension and chronic-throembolic pulmonary hypertension.· Have been told by your healthcare provider to not have sexual activity because of health problems.
12.3 Pharmacokinetics
Nitrates can also be found in other medicines such as isosorbide dinitrate or isosorbide mononitrate. Some recreational drugs called “poppers” also contain nitrates, such as amyl nitrate and butyl nitrate. Do not use vardenafil hydrochloride orally disintegrating tablets if you are using these drugs. Ask your doctor or pharmacist if you are not sure if any of your medicines are nitrates.· Take riociguat, a guanylate cyclase stimulator, a medicine that treats pulmonary arterial hypertension and chronic-throembolic pulmonary hypertension.· Have been told by your healthcare provider to not have sexual activity because of health problems. Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease.WHAT SHOULD YOU DISCUSS WITH YOUR DOCTOR BEFORE TAKING VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?
J. Chromatogr. A
Before taking vardenafil hydrochloride orally disintegrating tablets, tell sex erection tablet your doctor about all your medical problems, including if you:· Have heart problems such as angina, heart failure, irregular heartbeats, or have had a heart attack. Ask your doctor if it is safe for you to have sexual activity.· Have low blood pressure or have high blood pressure that is not controlled.· Have pulmonary hypertension· Have had a stroke.· Have had a seizure.· Or any family members have a rare heart condition known as prolongation of the QT interval (long QT syndrome).· Have liver problems.· Have kidney problems and require dialysis.· Have retinitis pigmentosa, a rare genetic (runs in families) eye disease.· Have ever had severe vision loss, or if you have an eye condition called non-arteritic anterior ischemic optic neuropathy (NAION).· Have stomach ulcers.· Have a bleeding problem.· Have a deformed penis shape or Peyronie’s disease.· Have had an erection that lasted more than 4 hours.· Have blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia.· Have hearing problems.· Have phenylketonuria.· Have fructose intolerance.CAN OTHER MEDICATIONS AFFECT VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Vardenafil hydrochloride orally disintegrating tablets and other medicines may affect each other. Always check with your doctor before starting or stopping any medicines. Especially tell your doctor if you take any of the following:· Medicines called nitrates (see “What important information should you know about vardenafil hydrochloride orally disintegrating tablets?”).• Medicines containing cobicistat.· Medicines that treat abnormal heartbeat.
Dosage for adults 65 years or older
These include quinidine, procainamide, amiodarone and sotalol.· Ritonavir (Norvir®) or indinavir sulfate (Crixivan®) saquinavir (Fortavase® or Invirase®) or atazanavir (Reyataz®) or other HIV protease inhibitors.· Ketoconazole or itraconazole (such as Nizoral® or Sporanox®).• Cobicistat· Erythromycin or clarithromycin.· Other medicines or treatments for ED.Patients taking these drugs should not use vardenafil hydrochloride orally disintegrating tablets.Patients taking alpha-blockers should not initiate vardenafil therapy with vardenafil hydrochloride orally disintegrating tablets. Patients taking alpha-blockers who have previously used vardenafil film-coated tablets may switch to vardenafil hydrochloride orally disintegrating tablets at the advice of their healthcare provider.· Medicines called alpha-blockers. Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. In some patients the use of PDE5 inhibitor drugs, including vardenafil hydrochloride orally disintegrating tablets, with alpha-blockers can lower blood pressure significantly leading to fainting.· Patients should contact the prescribing physician if alpha-blockers or other drugs that lower blood pressure are prescribed by another healthcare provider.HOW SHOULD YOU TAKE VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Take vardenafil hydrochloride orally disintegrating tablets exactly as your doctor prescribes. Vardenafil hydrochloride orally disintegrating tablets comes in 10 mg orally disintegrating tablets. Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease.WHAT SHOULD YOU DISCUSS WITH YOUR DOCTOR BEFORE TAKING VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS? Before taking vardenafil hydrochloride orally disintegrating tablets, tell sex erection tablet your doctor about all your medical problems, including if you:· Have heart problems such as angina, heart failure, irregular heartbeats, or have had a heart attack.
Do erectile dysfunction medicines increase sexual desire?
You and your doctor should talk about vardenafil hydrochloride orally disintegrating tablets when you start taking it and at regular checkups. If you do not understand the information, or have questions, talk with your doctor or pharmacist.WHAT IMPORTANT INFORMATION SHOULD YOU KNOW ABOUT VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Vardenafil hydrochloride orally disintegrating tablets are not interchangeable with vardenafil film-coated tablets (LEVITRA).Vardenafil hydrochloride orally disintegrating tablets can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. With a sudden drop in blood pressure, you could get dizzy, faint, or have a heart attack or stroke.Vardenafil hydrochloride orally disintegrating tablets contain phenylalanine which can be harmful to people who have phenylketonuria. Talk to your doctor if you have phenylketonuria.Do not take vardenafil hydrochloride orally disintegrating tablets if you:· Take any medicines called “nitrates” (often used to control chest pain, also known as angina)· Use recreational drugs called “poppers” like amyl nitrate and butyl nitrate.· Take riociguat (Adempas®), a guanulate cyclase stimulator, a medicine that treats pulmonary arterial hypertension and chronic-thromboembolic pulmonary hypertension. (See “Who Should Not Take Vardenafil Hydrochloride Orally Disintegrating Tablets?”)Tell all your healthcare providers that you take vardenafil hydrochloride orally disintegrating tablets.
Dosage for people with kidney disease
If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took vardenafil hydrochloride orally disintegrating tablets.WHAT ARE VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Vardenafil hydrochloride orally disintegrating tablets are a prescription medicine taken by mouth for the treatment of erectile dysfunction (ED) in men.ED is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. A man who has trouble getting or keeping an erection should see his doctor for help if the condition bothers him. Vardenafil hydrochloride orally disintegrating tablets may help a man with ED get and keep an erection when he is sexually excited.Vardenafil hydrochloride orally disintegrating tablets does not:· Cure ED.· Increase a man’s sexual desire.· Protect a man or his partner from sexually transmitted diseases, including HIV. Speak to your doctor about ways to guard against sexually transmitted diseases.· Serve as a male form of birth control.Vardenafil hydrochloride orally disintegrating tablets are only for men with ED. Vardenafil hydrochloride orally disintegrating tablets are not for women or children.
Sensitive determination of anticancer drug imatinib in spiked human urine samples by differential pulse voltammetry on anodically pretreated boron-doped diamond electrode
Vardenafil hydrochloride orally disintegrating tablets must be used only under a doctor’s care.HOW DOES VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS WORK?When a man is sexually stimulated, his body’s normal physical response is to increase blood flow to his penis. Vardenafil hydrochloride orally disintegrating tablets helps increase blood flow to the penis and may help men with ED get and keep an erection satisfactory for sexual activity. Once a man has completed sexual activity, blood flow to his penis decreases, and his erection goes away.WHO CAN TAKE VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Talk to your doctor to decide if vardenafil hydrochloride orally disintegrating tablets are right for you.Vardenafil hydrochloride orally disintegrating tablets have been shown to be effective in men over the age of 18 years who have erectile dysfunction, including men with diabetes.WHO SHOULD NOT TAKE VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Do not take vardenafil hydrochloride orally disintegrating tablets if you:· Take any medicines called “nitrates” (see “What important information should you know about vardenafil hydrochloride orally disintegrating tablets?”). Nitrates are commonly used to treat angina. Angina is a symptom of heart disease and can cause pain in your chest, jaw, or down your arm.Medicines called nitrates include nitroglycerin that is found in tablets, sprays, ointments, pastes, or patches. Ask your doctor if it is safe for you to have sexual activity.· Have low blood pressure or have high blood pressure that is not controlled.· Have pulmonary hypertension· Have had a stroke.· Have had a seizure.· Or any family members have a rare heart condition known as prolongation of the QT interval (long QT syndrome).· Have liver problems.· Have kidney problems and require dialysis.· Have retinitis pigmentosa, a rare genetic (runs in families) eye disease.· Have ever had severe vision loss, or if you have an eye condition called non-arteritic anterior ischemic optic neuropathy (NAION).· Have stomach ulcers.· Have a bleeding problem.· Have a deformed penis shape or Peyronie’s disease.· Have had an erection that lasted more than 4 hours.· Have blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia.· Have hearing problems.· Have phenylketonuria.· Have fructose intolerance.CAN OTHER MEDICATIONS AFFECT VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Vardenafil hydrochloride orally disintegrating tablets and other medicines may affect each other. Always check with your doctor before starting or stopping any medicines. Especially tell your doctor if you take any of the following:· Medicines called nitrates (see “What important information should you know about vardenafil hydrochloride orally disintegrating tablets?”).• Medicines containing cobicistat.· Medicines that treat abnormal heartbeat.
What should I know about storage and disposal of this medication?
The dose is one vardenafil hydrochloride orally disintegrating tablet. Do not take more than one vardenafil hydrochloride orally disintegrating tablet a day. Doses should be taken at least 24 hours apart.· If you have prostate problems or high blood pressure, for which you take medicines called alpha-blockers, you should not start treatment for erectile dysfunction with vardenafil hydrochloride orally disintegrating tablets. Your doctor may prescribe a lower dose of vardenafil film-coated tablet.Take 1 vardenafil hydrochloride orally disintegrating tablet about 1 hour (60 min) before sexual activity. Some form of sexual stimulation is needed for an erection to happen with vardenafil hydrochloride orally disintegrating tablets.
Visual disturbances
Vardenafil hydrochloride orally disintegrating tablets may be taken with or without meals.Place on the tongue where it will dissolve rapidly. The tablet should be taken whole and not crushed or split.The tablet should not be taken with liquid.It should be taken immediately upon removal from the blister.Call your doctor or emergency room immediately if you accidentally took more vardenafil hydrochloride orally disintegrating tablets than prescribed.If you receive vardenafil hydrochloride orally disintegrating tablets in a blisterpack, examine the blisterpack before use. Do not use if blisters are torn, broken, or missing.WHAT ARE THE POSSIBLE SIDE EFFECTS OF VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?The most common side effects with vardenafil hydrochloride orally disintegrating tablets are headache, flushing, stuffy or runny nose, indigestion, upset stomach, dizziness, and back pain.
What do I do if I miss a dose?
These include quinidine, procainamide, amiodarone and sotalol.· Ritonavir (Norvir®) or indinavir sulfate (Crixivan®) saquinavir (Fortavase® or Invirase®) or atazanavir (Reyataz®) or other HIV protease inhibitors.· Ketoconazole or itraconazole (such as Nizoral® or Sporanox®).• Cobicistat· Erythromycin or clarithromycin.· Other medicines or treatments for ED.Patients taking these drugs should not use vardenafil hydrochloride orally disintegrating tablets.Patients taking alpha-blockers should not initiate vardenafil therapy with vardenafil hydrochloride orally disintegrating tablets.
- Vardenafil is used to treat erectile dysfunction in men.
- It works by increasing blood flow to the penis.
- Vardenafil is marketed under the brand name Levitra.
- The drug typically takes effect within 25-60 minutes.
Patients taking alpha-blockers who have previously used vardenafil film-coated tablets may switch to vardenafil hydrochloride orally disintegrating tablets at the advice of their healthcare provider.· Medicines called alpha-blockers.
- Vardenafil is part of phosphodiesterase inhibitors.
- It may interact with certain blood pressure medications.
- The drug is usually effective within 30 minutes.
- Store vardenafil in a cool, dry place away from children.
Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. In some patients the use of PDE5 inhibitor drugs, including vardenafil hydrochloride orally disintegrating tablets, with alpha-blockers can lower blood pressure significantly leading to fainting.· Patients should contact the prescribing physician if alpha-blockers or other drugs that lower blood pressure are prescribed by another healthcare provider.HOW SHOULD YOU TAKE VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?Take vardenafil hydrochloride orally disintegrating tablets exactly as your doctor prescribes. Vardenafil hydrochloride orally disintegrating tablets comes in 10 mg orally disintegrating tablets. The dose is one vardenafil hydrochloride orally disintegrating tablet. Do not take more than one vardenafil hydrochloride orally disintegrating tablet a day. Doses should be taken at least 24 hours apart.· If you have prostate problems or high blood pressure, for which you take medicines called alpha-blockers, you should not start treatment for erectile dysfunction with vardenafil hydrochloride orally disintegrating tablets. Your doctor may prescribe a lower dose of vardenafil film-coated tablet.Take 1 vardenafil hydrochloride orally disintegrating tablet about 1 hour (60 min) before sexual activity. Some form of sexual stimulation is needed for an erection to happen with vardenafil hydrochloride orally disintegrating tablets.
| Parameter | Value | Notes |
|---|---|---|
| Absorption Time | 30-60 minutes | Peak plasma concentration reached during this time |
| Half-life | 4-5 hours | Duration of drug activity |
| Bioavailability | Approximately 15% | Oral absorption efficiency |
| Metabolism | Via CYP3A4 enzyme | Liver processing of drug |
Vardenafil hydrochloride orally disintegrating tablets may be taken with or without meals.Place on the tongue where it will dissolve rapidly. The tablet should be taken whole and not crushed or split.The tablet should not be taken with liquid.It should be taken immediately upon removal from the blister.Call your doctor or emergency room immediately if you accidentally took more vardenafil hydrochloride orally disintegrating tablets than prescribed.If you receive vardenafil hydrochloride orally disintegrating tablets in a blisterpack, examine the blisterpack before use.
| Study/Source | Sample Size | Success Rate | Notes |
|---|---|---|---|
| Clinical Trial A | 150 men | 80% | Significant improvement in erectile function |
| Clinical Trial B | 200 men | 75% | Better outcomes with 10 mg dose compared to placebo |
| Real-world Reports | 300 patients | 78% | Effective in various age groups and conditions |
Do not use if blisters are torn, broken, or missing.WHAT ARE THE POSSIBLE SIDE EFFECTS OF VARDENAFIL HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS?The most common side effects with vardenafil hydrochloride orally disintegrating tablets are headache, flushing, stuffy or runny nose, indigestion, upset stomach, dizziness, and back pain.
