3 DOSAGE FORMS AND STRENGTHS

ED — When CIALIS is coadministered with an alpha-blocker in patients being treated for ED, patients should be stable on alpha-blocker therapy prior to

5.2 Potential for Drug Interactions When Taking CIALIS for Once Daily Use

Administration of CIALIS to patients using any form of organic nitrate is contraindicated. CIALIS was shown to potentiate the hypotensive effect of nitrates (4.1). History of known serious hypersensitivity reaction to CIALIS or ADCIRCA® (4.2). Administration with guanylate cyclase (GC) stimulators, such as riociguat (4.3). Patients should not use CIALIS if sex is inadvisable due to cardiovascular status (5.1).

Law360 is on it, so you are, too.

Use of CIALIS with alpha-blockers, antihypertensives or substantial amounts of alcohol (≥5 units) may lead to hypotension (5.6, 5.9). CIALIS is not recommended in combination with alpha-blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering. Caution is advised when CIALIS is used as a treatment for ED in men taking alpha-blockers. (2.7, 5.6, 7.1, 12.2) Patients should seek emergency treatment if an erection lasts >4 hours. Use CIALIS with caution in patients predisposed to priapism (5.3). initiating treatment, and CIALIS should be initiated at the lowest recommended dose

Product	Dosage	Quantity + Bonus	Price
Cialis Generic	20mg	90 + 6 Pills	154.71€ 147.34€	Buy
Cialis Generic	60mg	270 + 10 Pills	443.96€ 422.82€	Buy
Cialis Generic	20mg	270 + 10 Pills	335.21€ 319.25€	Buy
Cialis Professional	20mg	60 + 2 Pills	183.83€ 175.08€	Buy
Cialis Soft Tabs	20mg	270 + 10 Pills	471.40€ 448.95€	Buy
Cialis Professional	40mg	60 + 2 Pills	262.32€ 249.83€	Buy
Cialis Soft Tabs	20mg	180 + 8 Pills	353.17€ 336.35€	Buy
Cialis Professional	20mg	270 + 6 Pills	623.07€ 593.40€	Buy
Cialis Soft Tabs	20mg	10 Pills	39.03€ 37.17€	Buy
Cialis Generic	40mg	180 + 10 Pills	277.29€ 264.09€	Buy
Cialis Original	20mg	48 + 4 Pills	224.69€ 213.99€	Buy

[see Warnings and Precautions (5.6), Drug Interactions (7.1), and Clinical Pharmacology (12.2)].

5.11 Combination With Other PDE5 Inhibitors or Erectile Dysfunction Therapies

Patients should stop CIALIS and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION). CIALIS should be used with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION. Patients with a "crowded" optic disc may also be at an increased risk of NAION (5.4, 6.2). Patients should stop CIALIS and seek prompt medical attention in the event of sudden decrease or loss of hearing (5.5). Prior to initiating treatment with CIALIS for BPH, consideration should be given to other urological conditions that may cause similar symptoms (5.14).

5.3 Prolonged Erection

Most common adverse reactions (≥2%) include headache, dyspepsia, back pain, cheapt cialis soft myalgia, nasal congestion, flushing, and pain in limb (6.1). To report SUSPECTED ADVERSE REACTIONS, contact Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) or FDA at 1-800-FDA-1088 or CIALIS can potentiate the hypotensive effects of nitrates, alpha-blockers, antihypertensives or alcohol (7.1). ketoconazole, ritonavir) increase CIALIS exposure (2.7, 5.10, 7.2) requiring dose adjustment: CIALIS for use as needed: no more than 10 mg every 72 hoursCIALIS for once daily use: dose not to exceed 2.5 mg CIALIS for use as needed: no more than 10 mg every 72 hours CIALIS for once daily use: dose not to exceed 2.5 mg Hepatic Impairment (2.6, 5.8, 8.6): Mild or Moderate: Dosage adjustment may be needed. Renal Impairment (2.6, 5.7, 8.7): Patients with creatinine clearance 30 to 50 mL/min: Dosage adjustment may be needed. Patients with creatinine clearance less than 30 mL/min or on hemodialysis: For use as needed: Dose should not exceed 5 mg every 72 hours. Three strengths of almond-shaped tablets are available in different sizes and different shades

Study / Source	Effectiveness (%)	Comments
Clinical Trial 2022	70-80%	Used in men with ED
Patient Surveys	75%	Reported satisfaction with Cialis
Comparative Studies	Slightly better than Viagra	Longer duration of effect
Real-world Data	78%	Consistent effectiveness

of yellow: 5 mg tablets debossed with “C 5” 10 mg tablets debossed with

• Cialis is sometimes combined with psychological counseling for ED.
• Lifestyle factors, such as diet and exercise, can impact Cialis outcomes.
• Lilly supports research into ED causes and therapies.
• Psychological stress may reduce Cialis effectiveness.
• Cialis’s long half-life allows for flexible timing of dosages.
• Sexual partners may also benefit from understanding ED treatment.
• Proper storage prevents Cialis degradation and loss of potency.
• Research indicates Cialis may help vascular function overall.
• Patient confidentiality is maintained during Cialis prescription.
• Cialis is not a recreational drug; misuse can have health risks.
• Regular health checks recommended for chronic Cialis users.
• Patient testimonials often highlight increased quality of life.

“C 10” 20 mg tablets debossed with “C 20” Administration of CIALIS to patients

Warnings & Precautions

Creatinine clearance 30 to 50 mL/min: A starting dose of 5 mg not more than once per day is recommended, and the maximum dose is 10 mg not more than once in every 48 hours. Creatinine clearance less than 30 mL/min or on hemodialysis: The maximum dose is 5 mg not more than once in every 72 hours [see Warnings and Precautions (5.7) and Use in Specific Populations (8.7)]. Benign Prostatic Hyperplasia and Erectile Dysfunction/Benign Prostatic Hyperplasia Creatinine clearance 30 to 50 mL/min: A starting dose of 2.5 mg is recommended. An increase to 5 mg may be considered based on individual response. Creatinine clearance less than 30 mL/min or on hemodialysis: CIALIS for once daily use is not recommended [see Warnings and Precautions (5.7) and Use in Specific Populations (8.7)]. who are using any form of organic nitrate, either regularly and/or intermittently, is contraindicated. In clinical pharmacology studies, CIALIS was shown to potentiate the hypotensive effect of nitrates [see Clinical Pharmacology (12.2)].

5 Answers

The recommended starting dose of CIALIS for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity. The CIALIS dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability. The recommended dose of CIALIS for once daily use is 5 mg, taken at approximately the same time every day. When therapy for BPH is initiated with CIALIS and finasteride, the recommended dose of CIALIS for once daily use is 5 mg, taken at approximately the same time every day for up to 26 weeks. The recommended dose of CIALIS for once daily use is 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity. CIALIS is contraindicated in patients with a known serious hypersensitivity to tadalafil (CIALIS or ADCIRCA®).

Overdose/Missed Dose

21, 2012 -- Eli Lilly and Company (LLY) announced today it has received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in the European Union (EU), recommending approval of Cialis 5 mg for once daily use for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). Before taking Cialis, tell your healthcare provider about all your medical problems, particularly if you have or ever had: heart problems such as chest pain (angina), heart failure, irregular heartbeats, or have had a heart attack high or low blood pressure or have high blood pressure that is not controlled stroke liver or kidney problems or require dialysis retinitis pigmentosa, a rare genetic (runs in families) eye disease severe vision loss, including a condition called NAION stomach ulcers or a bleeding problem a deformed penis shape or Peyronie's disease an erection that lasted more than 4 hours blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia Tell your healthcare provider about all the medicines you take especially if you take: medicines called "nitrates" which are often prescribed for chest pain alpha-blockers often prescribed for prostate problems blood pressure medications medicines for HIV or some types of oral antifungal medications some types of antibiotics such as clarithromycin, telithromycin, erythromycin (several brand names exist, please contact your healthcare provider to determine if you are taking this medicine) other medicines or treatments for erectile dysfunction (ED) Cialis is also marketed as Adcirca for the treatment of pulmonary arterial hypertension. cure ED increase a man's sexual desire protect a man or his partner from sexually transmitted diseases, including HIV serve as a male form of birth control For additional information, talk to your doctor and see full Patient Information at and Prescribing Information at or visit for more information. Package insert / product label Generic name: tadalafil Dosage form: tablet, film coated Drug class: Impotence medications CIALIS® is a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of: the signs and symptoms of benign prostatic hyperplasia (BPH) (1.2) ED and the signs and symptoms of BPH (ED/BPH) (1.3) If CIALIS is used with finasteride to initiate BPH treatment, such use is recommended for up to 26 weeks (1.4). CIALIS for use as needed: ED: Starting dose: 10 mg as needed prior to sexual activity.

Does tadalafil interact with foods or drinks?

Increase to 20 mg or decrease to 5 mg based upon efficacy/tolerability. Improves erectile function compared to placebo up to 36 hours post dose. Not to be taken more than once per day (2.1). ED: Starting dose: 10 mg as needed prior to sexual activity. CIALIS may be taken without regard to food (2.5). Hypersensitivity reactions have been reported, including Stevens-Johnson syndrome and exfoliative dermatitis [see Adverse Reactions (6.2)].

• The Cialis patent expired in many countries by the mid-2020s.
• Generic tadalafil versions became widely accessible to patients.
• Market competition led to reduced prices for Cialis and generics.
• Lilly continues research on improved formulations of tadalafil.
• Online pharmacies sell Cialis; caution is advised to avoid counterfeits.
• The drug should only be purchased through licensed distributors.
• Awareness campaigns educate about safe use of Cialis.
• Side effect profiles remain similar between brand and generic versions.
• Pharmacovigilance monitors adverse events linked to Cialis use.
• Cialis remains an important option in ED treatment algorithms.
• The medication plays a role in men's sexual health discussions.
• Physicians frequently review Cialis use during follow-up visits.

Evaluation of erectile dysfunction and BPH should include an appropriate medical assessment to identify potential underlying causes, as well as treatment options.

• Cialis tablets come with different packaging, including blister packs and bottles.
• Eli Lilly provides comprehensive patient information leaflets with Cialis.
• Cialis is sometimes prescribed off-label for Raynaud’s phenomenon.
• The medication has a bioavailability of about 80%.
• Food intake has minimal impact on Cialis absorption.
• Cialis is metabolized primarily by the liver enzyme CYP3A4.
• Dose adjustments might be necessary for patients with kidney impairment.
• Cialis’s half-life is approximately 17.5 hours, contributing to long effect.
• Lilly has faced generic competition for Cialis in many markets.
• The drug’s patent expiration allowed entry of tadalafil generics.
• Cialis is included in some clinical guidelines for ED management.
• Monitoring for rare but serious side effects is part of patient care.

Before prescribing CIALIS, it is important to note the following: Physicians should consider the cardiovascular

8. Use In Specific Populations

See 17 for PATIENT COUNSELING INFORMATION and FDA-approved patient labeling. CIALIS is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). CIALIS is indicated for the treatment of ED and the signs and symptoms of BPH (ED/BPH). If CIALIS is used with finasteride to initiate BPH treatment, such use is recommended for up to 26 weeks because the incremental benefit of CIALIS decreases from 4 weeks until 26 weeks, and the incremental benefit of CIALIS beyond 26 weeks is unknown [see Clinical Studies (14.3)]. Do not split CIALIS tablets; entire dose should be taken.

17.10 Sexually Transmitted Disease

The recommended starting dose of CIALIS for use as needed in most patients is 10 mg, taken prior to anticipated sexual activity. The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The maximum recommended dosing frequency is once per day in most patients. CIALIS for use as needed was shown to improve erectile function compared to placebo up to 36 hours following dosing. Therefore, when advising patients on optimal use of cialis 10mg prescription CIALIS, this should be taken into consideration. status of their patients, since there is a degree of cardiac risk associated with sexual activity.

Mechanism of action

Mild or moderate (Child Pugh Class A or B): The dose should not exceed 10 mg once per day. The use of CIALIS once per day has not been extensively evaluated in patients with hepatic impairment and therefore, caution is advised. Severe (Child Pugh Class C): The use of CIALIS is not recommended [see Warnings and Precautions (5.8) and Use in Specific Populations (8.6)]. Mild or moderate (Child Pugh Class A or B): CIALIS for once daily use has not been extensively evaluated in patients with hepatic impairment. Therefore, caution is advised if CIALIS for once daily use is prescribed to these patients.