^ "Hidden Risks of Erectile Dysfunction 'Treatments' Sold Online". Archived from the original on 23 April 2019. ^ R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 9th edition, Biomedical Publications, Seal Beach, CA, 2011, pp. Archived from the original (PDF) on 10 September 2011.
| Parameter | Description | Typical Values | Notes |
|---|---|---|---|
| Absorption Rate | Time to reach peak plasma levels | 30-120 minutes | Varies with food intake |
| Half-Life | Duration of drug activity | 4 hours | Metabolized mainly in liver |
| Bioavailability | Percentage of drug absorbed | 40-50% | Affected by gastric pH |
| Metabolism | Enzymes involved | CYP3A4 | Liver metabolism mainly |
| Excretion | How drug is eliminated | Feces and urine | Mainly fecal excretion |
"Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules". ^ a b Webb DJ, Freestone S, Allen MJ, Muirhead GJ (March 1999). "Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist". ^ Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA (May 1998). "Oral sildenafil in the treatment of erectile dysfunction. Archived sildenafil gel from the original on 14 January 2012. "Onset and duration of action of sildenafil for the treatment of erectile dysfunction". ^ "Scientist who developed Viagra receives knighthood in New Year's Honours". Archived from the original on 14 January 2023. "Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond". Archived from the original on 26 September 2008. Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments. Morriston Hospital in Swansea, was the first in the world to trial Viagra!
- Female sexual dysfunction affects millions worldwide, prompting research into treatments.
- Sildenafil is part of a broader conversation about women’s sexual health innovations.
- The role of sildenafil in improving orgasm quality is still being studied.
- It is essential to distinguish between clinical trial results and off-label use.
- Some women experience mood improvement alongside physical effects with sildenafil.
- Education about both benefits and risks is crucial for women considering sildenafil.
^ Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, et al. "Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction".
Mechanism of action
Food and Drug Administration (FDA). Archived from the original on 31 March 2021. Archived from the original on 12 August 2025. ^ "Sildenafil Drug Usage Statistics, United States, 2014 - 2023". "Generic Viagra: Two versions of sildenafil hit the market today".
Pulmonary hypertension
Archived from the original on 25 November 2018. Archived from the original on 12 February 2022. "With Viagra Now Available Over-The-Counter In The U.K., Will The U.S. "Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus". "Strategies for managing sexual dysfunction induced by antidepressant medication".
Can Viagra make a woman wet?
The Cochrane Database of Systematic Reviews (5) CD003382. Archived from the original on 10 October 2020. "Efficacy and safety of sildenafil treatment in pulmonary arterial hypertension: a systematic review". Archived from the original on 29 August 2021. "Raynaud's phenomenon and digital ischaemia--pharmacologic approach and alternative treatment options". "Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction". "Drug repositioning: identifying and developing new uses for existing drugs".
- Sildenafil may help women with conditions like arousal disorder, but evidence varies.
- There is ongoing research into safe, effective female-specific doses of sildenafil.
- Side effects experienced by women can include dizziness, nausea, or visual disturbances.
- Consumption of alcohol while on sildenafil can increase side effect risks.
- Female sexual dysfunction can have psychological, hormonal, and physical causes.
- Sildenafil is not a cure-all; proper diagnosis is important for targeted treatment.
Archived from the original on 22 April 2019. Archived from the original on 10 June 2019. "Health situation in former communist bloc is dire, says Unicef".
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Polo | 100mg | 84 + 4 Pills | 244.49€ 232.85€ | |
| Viagra Generic | 150mg | 180 + 10 Pills | 236.46€ 225.20€ | |
| Kamagra Soft Tabs | 100mg | 84 + 4 Pills | 233.05€ 221.95€ | |
| Viagra Generic | 200mg | 10 Pills | 40.96€ 39.01€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Kamagra Soft Tabs | 100mg | 20 Pills | 79.79€ 75.99€ | |
| Viagra Generic | 25mg | 360 + 10 Pills | 213.68€ 203.50€ | |
| Viagra Generic | 25mg | 270 + 8 Pills | 184.26€ 175.49€ | |
| Viagra Generic | 100mg | 30 + 4 Pills | 60.91€ 58.01€ | |
| Viagra Generic | 200mg | 180 + 10 Pills | 277.56€ 264.34€ | |
| Kamagra Soft Tabs | 100mg | 272 + 12 Pills | 593.42€ 565.16€ |
Archived from the original on 1 November 2012. ^ Gurevich M, Cormier N, Leedham U, Brown-Bowers A (August 2018).
- Female patients should be cautious with sildenafil due to lack of approval.
- Erectile dysfunction medications can interact with other drugs, affecting women as well.
- Some studies suggest sildenafil may help women with arousal issues but are inconclusive.
- Sildenafil may improve clitoral blood flow, enhancing sensitivity.
- Libido enhancement from sildenafil varies based on individual health factors.
- Self-medicating women with sildenafil without supervision can be risky.
Sexuopharmaceutical use by men as prevention and proficiency". "Spreading the Word, but What Word is That? Viagra and Male Sexuality in Popular Culture". "A new view of women's sexual problems: Why new? Archived from the original on 3 January 2009. Archived from the original on 12 October 2008. "Sales of Impotence Drugs Fall, Defying Expectations". Archived from the original on 11 October 2007. ^ "Pfizer Courting More Controversy with Viagra 'Advergaming'". Archived from the original on 19 December 2019. Archived from the original on 6 May 2018. Archived from the original on 9 January 2009. Archived from the original on 22 February 2021. ^ a b "Viagra now available over the counter without prescription in the UK". Archived from the original on 26 March 2021. Archived from the original on 8 December 2013. "The coming generics threat to Pfizer's Viagra brand just got scarier". Archived from the original on 9 September 2017.
THE BIG “O” (OVERVIEW)
Archived from the original on 4 September 2014. "Recreational use and misuse of phosphodiesterase 5 inhibitors". Archived from the original on 21 August 2016. "Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time". ^ McCambridge J, Mitcheson L, Hunt N, Winstock A (March 2006).
Corresponding author
"The rise of Viagra among British illicit drug users: 5-year survey data". "Does marijuana use play a role in the recreational use of sildenafil?". Archived from the original on 26 January 2013. "Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules". Proceedings of the National Academy of Sciences of the United States of America.
Addyi (filbanserin)
"Source: Roger Clemens, host of athletes pop Viagra to help onfield performance". Archived from the original on 14 August 2020. "Bears' Brandon Marshall says some NFL players use Viagra .. on the Field". Archived from the original on 5 March 2016. ^ "Viagra to go generic in 2017 according to Pfizer agreement".
- Doctors may prescribe sildenafil off-label for women based on individual assessment.
- Patient education about realistic expectations is essential when using sildenafil.
- Sildenafil’s mechanism involves enhancing nitric oxide signaling in blood vessels.
- Women with liver or kidney problems need careful evaluation before sildenafil use.
- Viagra was initially tested for women before focusing on men’s erectile issues.
- Alternative options like vaginal lubricants are also common for female sexual problems.
Archived from the original on 1 December 2017. "Sex, Drugs and That Little Blue Pill". Archived from the original on 6 December 2017. "Why Pfizer Is About to Slash Viagra's Price in Half". Archived from the original on 7 December 2017. "Pfizer to lose patent of drug Viagra, Indian companies gear up with copycat versions: Pfizer's patent for the formulation of Viagra, used to treat impotence in men, ends in the US in 2020". Archived from the original on 17 April 2021. ^ "Set to conquer US, Indian 'Viagras' may give Pfizer a hard Time". Archived from the original on 22 December 2020. ^ a b "Pfizer Settles Viagra® Patent Litigation With Teva". "Lockout Supplements Issues Voluntary Nationwide Recall of Boner Bears Chocolate Syrup Due to Undeclared Sildenafil".
Does Viagra work for women?
Archived from the original on 12 October 2020. ^ "Viagra 25mg film-coated tablets Summary of Product Characteristics (SmPC)". ^ "Viagra Connect 50 mg film-coated tablets Summary of Product Characteristics (SmPC)". Archived from the original on 13 August 2020. Archived from the original on 11 October 2020.
Addyi (Flibanserin)
Archived from the original on 11 November 2020. ^ Nichols DJ, Muirhead GJ, Harness JA (6 March 2002). "Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality". The American Society of Health-System Pharmacists. Archived from the original on 23 April 2020.
How it Helps You Do It
PDE-5 inhibitors appear to have significant but moderate efficacy in secondary [Raynaud's phenomenon]. "Sublingual sildenafil in the treatment of erectile dysfunction: faster onset of action with less dose". "The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction". ^ "Drug Approval Package: Viagra (sildenafil citrate) NDA #020895". U.S. Archived from the original on 19 November 2016. "Counterfeit Viagra, Cialis, Levitra: The Ultimate Guide".
| Brand Name | Formulation | Dosage Options | Notes |
|---|---|---|---|
| Viagra Women | Oral tablet | 25 mg, 50 mg | Off-label use, not approved by FDA |
| Female Arousal Gel | Topical gel | N/A | Claimed to enhance blood flow |
| Sildenafil Citrate | Generic oral tablet | 25-100 mg | Widely used off-label in women |
| Custom Compounded | Customized formulations | Variable | Prescribed by special clinics |
Archived from the original on 10 January 2017. "Online pharmacies suspected of counterfeit drug sales". ^ "Erectile Dysfunction Medication the Most Seized Drug During Global Crackdown, Interpol Says". ^ "Global illicit medicines targeted by INTERPOL operation". Archived from the original on 10 December 2023. ^ "Israeli-made AI exposes international fake Viagra network". ^ "Counterfeit Viagra Pills, Footwear, Belts, Car Emblems and Headphones Worth over $32 Million Seized at the LA/Long Beach Seaport U.S.
| Medication Type | Interaction Effect | Risk Level | Notes |
|---|---|---|---|
| Nitrates | Severe hypotension | High | Contraindicated |
| Alpha-Blockers | Increased risk of hypotension | Moderate | Dose adjustment may be needed |
| CYP3A4 Inhibitors | Increased sildenafil levels | Moderate to high | Watch for adverse effects |
| CYP3A4 Inducers | Decreased effectiveness | Moderate | Alternative treatments considered |
Customs and Border Protection". Archived from the original on 12 October 2013. "Yes, There Is a Way to Get Generic Viagra". Archived from the original on 2 May 2016. "Pfizer Wins Viagra Patent Infringement Case Against Teva Pharmaceuticals". Archived from the original on 11 January 2015. ^ "Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan". Retrieved 17 June 2024 – via Business Wire. Archived from the original on 17 June 2024.
See also:
"Efficacy of Sildenafil on healthy humans in high‑altitude hypoxia at rest and during exercise: A meta‑analysis". "Interventions for preventing high altitude illness: Part 1. Archived from the original on 10 June 2017. ^ "FDA Updates Labeling for Viagra, Cialis and Levitra for Rare Post-Marketing Reports of Eye Problems" (Press release). Archived from the original on 22 October 2016.
Osphenia (Ospemifene)
"Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date". ^ "FDA Announces Revisions to Labels for Cialis, Levitra and Viagra". "Drug interactions with phosphodiesterase-5 inhibitors used for the treatment of erectile dysfunction or pulmonary hypertension". "Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions". Use of sildenafil (Viagra) in patients with cardiovascular disease.
What side effects can low dose sildenafil cause?
American College of Cardiology/American Heart Association". Journal of the American College of Cardiology. ^ "Viagra (Sildenafil Citrate): Side Effects, Interactions, Warning, Dosage & Uses". Archived from the original on 12 July 2018. "Young men add Viagra to their drug arsenal". "Viagra patent expires in June, says Brazilian court". Archived from the original on 17 April 2012.
What Are the Side Effects in Women?
"Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks". "Detection of sildenafil analogues in herbal products for erectile dysfunction". Archived from the original on 4 March 2016. ^ "FDA Warns Consumers About Dangerous Ingredients in "Dietary Supplements" Promoted for Sexual Enhancement". Archived from the original on 18 January 2017. ^ "Revatio patent ruled invalid for lack of sound prediction and obviousness". Archived from the original on 3 March 2016. {{cite web}}: CS1 maint: deprecated archival service (link) ^ Teva Canada Ltd. v. Pfizer Canada Inc., 2012 SCC 60 at par. "Supreme Court ruling could lead to cheaper versions of Viagra". Archived from the original on 10 March 2013. "Canadian Supreme court rules Viagra patent invalid". Archived from the original on 11 November 2012. ^ "Viagra patent tossed out by Supreme Court: Decision allows generic versions of drug to be produced".
