Fertility and Sterility, Volume 118, Issue 5, e4. Cowan, B, Walker, K., Rodgers, K., Agyemang, J. Regret Regarding Fertility Preservation Decisions Among Male Cancer Patients.
Cobra 120mg Dosage Guidelines
This helps you achieve and maintain a hard, erect penis suitable for sexual activity. [1][2][4][5][7][8][10][24][27][33][41][56][57][67][91][131] Brand Name: Vybrique, ViagraClasses: Phosphodiesterase Type 5 Inhibitors (24:08.12), Phosphodiesterase type 5 inhibitors (48:48.24) Sildenafil citrate (Viagra® and generic equivalents) is used orally for the treatment of erectile dysfunction (ED, impotence). [1][4][6][7][8][9][10][25][33][34][67][81][102][104][105][107][108][112][118][126][127][128][129][130][131][132][133][134][140][142][143][144][189] A thorough medical, sexual and psychosocial history, physical examination, and selective laboratory testing should be undertaken to diagnose ED, determine potential underlying causes, exclude potentially reversible or treatable causes (e.g., hypogonadism with inadequate testosterone replacement, hyperprolactinemia, drug-induced dysfunction, dyslipidemias, alcoholism, other substance abuse, hypertension, thyroid disease, cardiovascular or cerebrovascular disease, neurologic disease, adrenal dysfunction, psychologic dysfunction, marital discord, smoking), and identify appropriate treatment in conjunction with or prior to initiating vasoactive therapy (e.g., PDE 5 type inhibitor). [12][28][30][31][57][65][66][70][78][83][94][144][145][160][161][189][601][602][603] A review of the patient's current drug regimens should be conducted to detect possible drug-induced ED (e.g., certain antihypertensive, antidepressant, antipsychotic, or antiarrhythmic agents); it may be possible to substitute alternative drug(s) that lessen the risk of such dysfunction. [12][28][70][81][118][144][161][602][603] In instances where substitution therapy is not feasible, concomitant vasoactive therapy with a PDE 5 sildenafil 25mg tablets type inhibitor may promote patient compliance by counteracting ED as an adverse effect.
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[12][28][70][81][118][144][161][602][603] Efficacy of sildenafil is variable in patients with ED, in part depending on the underlying etiology, severity, and dose employed, but the drug generally appears to be effective in restoring sexual function to an acceptable level in the majority of treated men. [1][7][8][9][10][25][33][34][65][76][81][101][104][105][126][127][131][142][143][144] The erectile response generally increases with increasing sildenafil dose and plasma drug concentration, with response becoming greater at 50- and 100-mg doses than at 25 mg.[1][8][9][33][126][130][131][155] Analyses of subgroups of patients with ED indicate that efficacy of sildenafil is not affected by race or age, duration of ED, or duration of select underlying disease states (e.g., diabetes mellitus), and the drug has been effective in a broad range of patients with ED, including those with a history of coronary artery disease (e.g., coronary artery bypass graft [CABG]), hypertension, other cardiac disease (including ischemic heart disease), peripheral vascular disease, type 1 or 2 diabetes mellitus, depression, radical prostatectomy, prostate brachytherapy, transurethral resection of the prostate (TURP), spina bifida, spinal cord injury, and in patients taking antidepressants, antipsychotics, diuretics, and antihypertensive agents. [1][25][30][33][34][93][101][102][104][105][107][108][112][118][126][127][128][129][130][131][132][133][134][140][144] Pooled data from numerous fixed-dose and flexible-dose studies in men with ED secondary to a broad spectrum of organic and psychogenic causes showed increases in mean rates of successful intercourse (total successes divided by total attempts) to about 66-69% in those receiving sildenafil compared with about 20-22% for placebo. Erectile response to sildenafil is better in patients whose erectile function is less impaired at treatment initiation (e.g., those with some spontaneous successful intercourse, with partial erections, with erections during sleep, or with psychogenic causes). [1][33][105][145] In one flexible-dose study (dosage titration and maintenance up to 100 mg), mean scores for number of successful penetrations returned to normal in a subgroup of patients with psychogenic causes of ED; however, mean scores for maintenance of erections during intercourse in these men were lower than in untreated healthy men. The Journal of Urology, 201(Supplement 4), e680-e681. Feasibility Study of Video Telehealth Clinic Visits in Urology. The Journal of Urology, 201(Supplement 4), e545-e545. Erectile dysfunction is a condition in which you have trouble getting or keeping an erection firm enough for satisfying sex.
- Overuse of sildenafil 120 mg may result in severe headache and nausea.
- Alcohol can reduce sildenafil effectiveness and worsen side effects.
- Always follow the doctor’s instructions for dosing and timing.
- Sildenafil should be stored away from moisture, heat, and light.
- Do not mix sildenafil with recreational drugs like 'poppers' or stimulants.
- Sudden vision loss is rare but requires immediate medical attention.
Erectile dysfunction affects as many as 30 million men in the United States.
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Premature ejaculation (PE) is a sexual dysfunction characterized by a short ejaculatory latency, a perceived lack of control about the timing of ejaculation, and distress and interpersonal difficulty related to ejaculating too quickly. Low testosterone or testosterone deficiency, also known as hypogonadism, is a condition in which patients develop symptoms such as low sex drive, erectile dysfunction (ED), and fatigue because the body doesn’t produce enough testosterone.
Why is this medication prescribed?
Though many men don’t like to talk about it, ejaculation problems are very common. Some of the most common issues include premature, delayed, or retrograde ejaculation. Your pelvic floor is a lot like plumbing in your home: chew sildenafil you never really think about it unless something goes wrong. When you think of male sexual dysfunction, concerns like erectile dysfunction (ED) or premature ejaculation (PE) probably come to mind first. But there’s another sex-related issue that’s more common in men than you might expect: difficulty orgasming.
1. Regulatory Documentation Provided
KEEP MEDICINE OUT OF REACH OF CHILDREN. SWALLOW WHOLE DO NOT CHEW OR CRUSH. Do not use Sildenafil tablet if you have recently taken nitrates (medicines used in angina or chest pain). SCHEDULE: SCHEDULE ‘H’ PRESCRIPTION DRUG WARNING: To be sold by retail on the prescription of a Registered Medical Practitioner only. Sildenafil Citrate Tablets IP 20mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Though many men don’t like to talk about it, ejaculation problems are very common. Some of the most common issues include premature, delayed, or retrograde ejaculation. Your pelvic floor is a lot like plumbing in your home: chew sildenafil you never really think about it unless something goes wrong.
Call to Action for Buyers, Importers, and Distributors
[33][34] In a study in men with ED secondary to radical prostatectomy receiving fixed-dose sildenafil (100 mg), response to therapy was greatest in those who had undergone bilateral-nerve-sparing surgery than in those who had undergone unilateral or non-nerve-sparing procedures. [104][127] Pooled data from various clinical trials indicate that sildenafil improved the erections of 43% of patients with ED secondary to radical prostatectomy compared with 15% of those receiving placebo. [1][104] A pooled analysis of 10 placebo-controlled studies of men with severe ED (organic etiology in 60%, psychogenic in 15%, and mixed in 25% of patients) treated with sildenafil (50-100 mg in fixed- or flexible-dose studies) indicated that 48% of the patients usually had erections sufficient for intercourse (score of 4, with 0 being unsuccessful and 5 being almost always successful) after treatment with sildenafil, compared with 8% of those receiving placebo. [76][127] In several randomized, double-blind, placebo-controlled studies in patients receiving sildenafil (flexible doses up to 100 mg or fixed doses ranging from 10-100 mg for 12 weeks) for the treatment of ED attributed to complications of diabetes mellitus, complications of spinal cord injury, or psychogenic causes, 48, 59, or 70% of all attempts at intercourse were successful, respectively, compared with 12, 13, or 29% of all attempts in those receiving placebo. [1][7][8][9][10][25][33][93] In these studies, sildenafil improved several aspects of sexual function including frequency, firmness, and maintenance of erection; frequency of orgasm; satisfaction and enjoyment of intercourse; and overall relationship satisfaction.
What should I know about sildenafil before taking it?
[1][8][9][33][94][107][130][131][142] Pooled data from fixed- and flexible-dose studies indicate that sildenafil (50 or 100 mg) has no effect on sexual desire (i.e., rates of attempted intercourse, which averaged about 2 per week), but the rate of success increased to an average of 1.3 events per patient per week from 0.4 events per week with placebo. [1][8][33][131] In part, the absence of an effect on sexual desire may be attributed to the fact that men enrolling in ED studies generally have a near-normal level of sexual desire upon study entry. [33][107][130][131] Improvement in erectile function sufficient for successful intercourse can be achieved with sildenafil in a substantial percentage of patients with ED, and the strength and duration of erection achieved with the drug in such patients approached those achieved in untreated healthy men. Sildenafil also has been effective in a limited number of men with temporary ED associated with the stress of providing a sperm sample (e.g., for intrauterine insemination or in vitro fertilization during assisted reproduction). [143] In men with a history of such temporary dysfunction, planned use of sildenafil for subsequent attempts at obtaining a sperm specimen may improve attainment of an erection adequate for self-stimulated ejaculation. When you think of male sexual dysfunction, concerns like erectile dysfunction (ED) or premature ejaculation (PE) probably come to mind first. But there’s another sex-related issue that’s more common in men than you might expect: difficulty orgasming. KEEP MEDICINE OUT OF REACH OF CHILDREN. SWALLOW WHOLE DO NOT CHEW OR CRUSH. Do not use Sildenafil tablet if you have recently taken nitrates (medicines used in angina or chest pain). SCHEDULE: SCHEDULE ‘H’ PRESCRIPTION DRUG WARNING: To be sold by retail on the prescription of a Registered Medical Practitioner only. Sildenafil Citrate Tablets IP 20mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 25mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 50mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 75mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 100mg Each Film coated tablet contains: Sildenafil Citrate IP Eq.
- Sildenafil citrate 120 mg can cause prolonged erections if misused.
- This dose may increase the risk of cardiovascular side effects.
- Always consult a healthcare provider before taking high doses of sildenafil.
- Combining sildenafil with nitrates can cause dangerous blood pressure drops.
- Side effects may include flushing, nasal congestion, and dizziness.
- Sildenafil is metabolized in the liver and excreted via feces and urine.
Sildenafil Citrate Tablets IP 120mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 130mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 150mg Each Film coated tablet contains: Sildenafil Citrate IP Eq.
| Property | Description | Typical Dose | Onset of Action | Duration of Effect | Mechanism of Action |
|---|---|---|---|---|---|
| Bioavailability | Approximately 40% | 120 mg | 30-60 minutes | Up to 6 hours | Inhibits PDE5 enzyme in smooth muscle |
| Half-life | Approximately 4 hours | N/A | N/A | N/A | Enhances nitric oxide signaling |
| Metabolism | Liver via CYP3A4 and CYP2C9 | N/A | N/A | N/A | Prevents cGMP breakdown |
| Excretion | Mainly via feces (80%), urine (13%) | N/A | N/A | N/A | Eliminates unchanged drug |
| Peak Plasma Levels | Achieved within 30-120 minutes | 120 mg | 30 minutes | N/A | Related to dose and absorption rate |
Sildenafil Citrate Tablets IP 200mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil tablets use sildenafil oral jelly 100 mg in treatment of Erectile dysfunction. It works by relaxing the blood vessels in your penis, thereby increasing blood flow into the penis on sexual stimulation. This helps you achieve and maintain a hard, erect penis suitable for sexual activity.
4.2 Hypersensitivity Reactions
Dosage for pulmonary arterial hypertension (PAH)
[1][2][4][5][7][8][10][24][27][33][41][56][57][67][91][131] Brand Name: Vybrique, ViagraClasses: Phosphodiesterase Type 5 Inhibitors (24:08.12), Phosphodiesterase type 5 inhibitors (48:48.24) Sildenafil citrate (Viagra® and generic equivalents) is used orally for the treatment of erectile dysfunction (ED, impotence). [1][4][6][7][8][9][10][25][33][34][67][81][102][104][105][107][108][112][118][126][127][128][129][130][131][132][133][134][140][142][143][144][189] A thorough medical, sexual and psychosocial history, physical examination, and selective laboratory testing should be undertaken to diagnose ED, determine potential underlying causes, exclude potentially reversible or treatable causes (e.g., hypogonadism with inadequate testosterone replacement, hyperprolactinemia, drug-induced dysfunction, dyslipidemias, alcoholism, other substance abuse, hypertension, thyroid disease, cardiovascular or cerebrovascular disease, neurologic disease, adrenal dysfunction, psychologic dysfunction, marital discord, smoking), and identify appropriate treatment in conjunction with or prior to initiating vasoactive therapy (e.g., PDE 5 type inhibitor). [12][28][30][31][57][65][66][70][78][83][94][144][145][160][161][189][601][602][603] A review of the patient's current drug regimens should be conducted to detect possible drug-induced ED (e.g., certain antihypertensive, antidepressant, antipsychotic, or antiarrhythmic agents); it may be possible to substitute alternative drug(s) that lessen the risk of such dysfunction. [12][28][70][81][118][144][161][602][603] In instances where substitution therapy is not feasible, concomitant vasoactive therapy with a PDE 5 sildenafil 25mg tablets type inhibitor may promote patient compliance by counteracting ED as an adverse effect. [12][28][70][81][118][144][161][602][603] Efficacy of sildenafil is variable in patients with ED, in part depending on the underlying etiology, severity, and dose employed, but the drug generally appears to be effective in restoring sexual function to an acceptable level in the majority of treated men.
- Sildenafil 120 mg can cause flushing and nasal congestion as common side effects.
- It is important to follow medical advice to minimize health risks.
- The drug's effectiveness can be influenced by other health conditions like diabetes.
- Consuming grapefruit or grapefruit juice may affect sildenafil’s metabolism.
- Patients should seek emergency care if experiencing an erection lasting longer than 4 hours.
- Sildenafil’s effects typically last about 4-6 hours, depending on individual factors.
[1][7][8][9][10][25][33][34][65][76][81][101][104][105][126][127][131][142][143][144] The erectile response generally increases with increasing sildenafil dose and plasma drug concentration, with response becoming greater at 50- and 100-mg doses than at 25 mg.[1][8][9][33][126][130][131][155] Analyses of subgroups of patients with ED indicate that efficacy of sildenafil is not affected by race or age, duration of ED, or duration of select underlying disease states (e.g., diabetes mellitus), and the drug has been effective in a broad range of patients with ED, including those with a history of coronary artery disease (e.g., coronary artery bypass graft [CABG]), hypertension, other cardiac disease (including ischemic heart disease), peripheral vascular disease, type 1 or 2 diabetes mellitus, depression, radical prostatectomy, prostate brachytherapy, transurethral resection of the prostate (TURP), spina bifida, spinal cord injury, and in patients taking antidepressants, antipsychotics, diuretics, and antihypertensive agents.
Detection in biological fluids
Fertility and Sterility, Volume 118, Issue 5, e4. Cowan, B, Walker, K., Rodgers, K., Agyemang, J. Regret Regarding Fertility Preservation Decisions Among Male Cancer Patients. The Journal of Urology, 201(Supplement 4), e680-e681. Feasibility Study of Video Telehealth Clinic Visits in Urology.
3. Affordable Pricing and Global Accessibility
The Journal of Urology, 201(Supplement 4), e545-e545. Erectile dysfunction is a condition in which you have trouble getting or keeping an erection firm enough for satisfying sex. Erectile dysfunction affects as many as 30 million men in the United States. Premature ejaculation (PE) is a sexual dysfunction characterized by a short ejaculatory latency, a perceived lack of control about the timing of ejaculation, and distress and interpersonal difficulty related to ejaculating too quickly. Low testosterone or testosterone deficiency, also known as hypogonadism, is a condition in which patients develop symptoms such as low sex drive, erectile dysfunction (ED), and fatigue because the body doesn’t produce enough testosterone. [1][25][30][33][34][93][101][102][104][105][107][108][112][118][126][127][128][129][130][131][132][133][134][140][144] Pooled data from numerous fixed-dose and flexible-dose studies in men with ED secondary to a broad spectrum of organic and psychogenic causes showed increases in mean rates of successful intercourse (total successes divided by total attempts) to about 66-69% in those receiving sildenafil compared with about 20-22% for placebo.
Discreet Packaging and Convenience
Erectile response to sildenafil is better in patients whose erectile function is less impaired at treatment initiation (e.g., those with some spontaneous successful intercourse, with partial erections, with erections during sleep, or with psychogenic causes). [1][33][105][145] In one flexible-dose study (dosage titration and maintenance up to 100 mg), mean scores for number of successful penetrations returned to normal in a subgroup of patients with psychogenic causes of ED; however, mean scores for maintenance of erections during intercourse in these men were lower than in untreated healthy men. [33][34] In a study in men with ED secondary to radical prostatectomy receiving fixed-dose sildenafil (100 mg), response to therapy was greatest in those who had undergone bilateral-nerve-sparing surgery than in those who had undergone unilateral or non-nerve-sparing procedures. [104][127] Pooled data from various clinical trials indicate that sildenafil improved the erections of 43% of patients with ED secondary to radical prostatectomy compared with 15% of those receiving placebo. [1][104] A pooled analysis of 10 placebo-controlled studies of men with severe ED (organic etiology in 60%, psychogenic in 15%, and mixed in 25% of patients) treated with sildenafil (50-100 mg in fixed- or flexible-dose studies) indicated that 48% of the patients usually had erections sufficient for intercourse (score of 4, with 0 being unsuccessful and 5 being almost always successful) after treatment with sildenafil, compared with 8% of those receiving placebo. [76][127] In several randomized, double-blind, placebo-controlled studies in patients receiving sildenafil (flexible doses up to 100 mg or fixed doses ranging from 10-100 mg for 12 weeks) for the treatment of ED attributed to complications of diabetes mellitus, complications of spinal cord injury, or psychogenic causes, 48, 59, or 70% of all attempts at intercourse were successful, respectively, compared with 12, 13, or 29% of all attempts in those receiving placebo.
- Side effects from high doses may include dizziness, flushing, or stomach upset.
- The onset of action is typically within 30 to 60 minutes after intake.
- Patients should avoid heavy meals before taking sildenafil for quicker results.
- Overdose symptoms include chest pain, loss of vision, and fainting.
- Sildenafil is not a cure for erectile dysfunction but enhances blood flow temporarily.
- Medical review is crucial for safety when considering high-dose sildenafil.
[1][7][8][9][10][25][33][93] In these studies, sildenafil improved several aspects of sexual function including frequency, firmness, and maintenance of erection; frequency of orgasm; satisfaction and enjoyment of intercourse; and overall relationship satisfaction.
| Use Case | Description | Dosage Recommendations | Special Considerations |
|---|---|---|---|
| Erectile Dysfunction (ED) | To improve blood flow to the penis during arousal | 120 mg as prescribed | Not for use with nitrates |
| Pulmonary Arterial Hypertension | Off-label for vasodilation in lungs | Under doctor guidance | Monitor blood pressure |
| Off-label Use in Sexual Dysfunction | Sometimes used in other sexual dysfunctions | As prescribed | Limited evidence for other uses |
| Enhancement of Exercise Capacity | Occasionally used in sports medicine | Not approved | Risk of adverse effects |
[1][8][9][33][94][107][130][131][142] Pooled data from fixed- and flexible-dose studies indicate that sildenafil (50 or 100 mg) has no effect on sexual desire (i.e., rates of attempted intercourse, which averaged about 2 per week), but the rate of success increased to an average of 1.3 events per patient per week from 0.4 events per week with placebo. [1][8][33][131] In part, the absence of an effect on sexual desire may be attributed to the fact that men enrolling in ED studies generally have a near-normal level of sexual desire upon study entry.
Sildenafil Citrate Tablets 120mg (NEOGRA) Technical Specification:
Sildenafil Citrate Tablets IP 25mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 50mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 75mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 100mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 120mg Each Film coated tablet contains: Sildenafil Citrate IP Eq.
THERAPEUTIC INDICATIONS:
Sildenafil Citrate Tablets IP 130mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 150mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil Citrate Tablets IP 200mg Each Film coated tablet contains: Sildenafil Citrate IP Eq. Sildenafil tablets use sildenafil oral jelly 100 mg in treatment of Erectile dysfunction. It works by relaxing the blood vessels in your penis, thereby increasing blood flow into the penis on sexual stimulation. [33][107][130][131] Improvement in erectile function sufficient for successful intercourse can be achieved with sildenafil in a substantial percentage of patients with ED, and the strength and duration of erection achieved with the drug in such patients approached those achieved in untreated healthy men. Sildenafil also has been effective in a limited number of men with temporary ED associated with the stress of providing a sperm sample (e.g., for intrauterine insemination or in vitro fertilization during assisted reproduction). [143] In men with a history of such temporary dysfunction, planned use of sildenafil for subsequent attempts at obtaining a sperm specimen may improve attainment of an erection adequate for self-stimulated ejaculation.
