Efficacy of 1, 5, and 20 mg oral sildenafil in the treatment of adults with pulmonary arterial hypertension: a randomized, double-blind study with open-label extension

Taking sildenafil with a nitrate medicine can cause

• Sildenafil should not be used with certain medications like alpha-blockers.
• Avoid alcohol consumption when taking sildenafil to reduce side effects.
• Discuss all medications with your doctor to prevent interactions.

a sudden and serious decrease in blood pressure.

Record Status

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian. For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Jet lag research

Choose an option Alt text (alternative text) helps when people can’t see the image or when it doesn’t load. Aim for 1-2 sentences that describe the subject, setting, or actions. This is used for ornamental images, like borders or watermarks. This alt text was created automatically and may be inaccurate. Downloading alt text AI model (0 of 0 MB) Automatic alt text Create alt text automaticallyDeleteDownload Suggests descriptions to help people who can’t see the image or when the image doesn’t load.

The International Index of Erectile Function

Runs locally on your device so your data stays private. Alt text editor Show alt text editor right away when adding an image Helps you make sure all your images have alt text. Pronunciation: sil-DEN-a-fil Generic name: sildenafil Brand names: Revatio, Viagra, Vybrique Dosage form: tablets (20 mg; 25 mg, 50 mg, 100 mg), injection (10 mg/12.5 mL), oral suspension (10 mg/mL), oral film (25 mg, 50 mg, 75 mg, 100 mg) Drug classes: Agents for pulmonary hypertension, Impotence medications Sildenafil is used to treat erectile dysfunction (ED) in adult men or pulmonary arterial hypertension (PAH) in adults and children, depending on the brand or formulation. Sildenafil tablets (25 mg, 50 mg, 100 mg; Viagra, generic) and sildenafil oral film (25 mg, 50 mg, 75 mg, 100 sildenafil pink pill mg; Vybrique) are used for ED. Sildenafil tablets (20 mg; Revatio, generic), sildenafil oral suspension (Revatio, generic), and sildenafil injection (Revatio, generic) are used for PAH. Some medicines can cause unwanted or dangerous effects when used with sildenafil.

Product	Dosage	Quantity + Bonus	Price
Viagra Generic	50mg	10 Pills	26.87€ 25.59€	Buy
Viagra Generic	100mg	20 Pills	45.58€ 43.41€	Buy
Kamagra Soft Tabs	100mg	32 Pills	120.11€ 114.39€	Buy
Kamagra Oral Jelly	100mg	21 Sachets	95.92€ 91.35€	Buy
Kamagra Polo	100mg	60 + 4 Pills	189.39€ 180.37€	Buy
Viagra Generic	25mg	90 + 6 Pills	105.03€ 100.03€	Buy
Viagra Generic	150mg	270 + 10 Pills	326.61€ 311.06€	Buy
Viagra Generic	150mg	30 + 2 Pills	72.32€ 68.88€	Buy
Kamagra	100mg	12 Pills	55.64€ 52.99€	Buy
Viagra Generic	200mg	20 Pills	61.69€ 58.75€	Buy
Viagra Generic	100mg	120 + 6 Pills	149.50€ 142.38€	Buy
Viagra Generic	200mg	120 + 8 Pills	204.80€ 195.05€	Buy
Viagra Generic	25mg	30 + 4 Pills	47.97€ 45.69€	Buy

Tell your doctor about all

• Sildenafil is used to treat erectile dysfunction and pulmonary hypertension.
• It belongs to the class of phosphodiesterase inhibitors.
• Oral sildenafil should be taken about 30-60 minutes before activity.

your current medicines, especially riociguat (Adempas).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website for more information. In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Do not let anyone else take your medication.

Usual Geriatric Dose for:

Ask your pharmacist any questions you have about refilling your prescription. Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies. Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA DOI: 10.1016/S0140-6736(05)60375-3 External LinkAlso available on ScienceDirect External Link The study by I Goldstein and colleagues1 provides the much needed data for scrutiny by the medical community with regard to the efficacy, mechanism of action, pharmacokinetics, dosing, and side-effects of sildenafil.

Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study

Since its approval by the Food and Drug Administration on March 27, 1998, sildenafil (marketed by Pfizer as Viagra) has been a pharmaceutical phenomenon. Its appeal stems from the fact that sildenafil is the first effective and safe oral therapy for men with erectile dysfunction.1–4 Pfizer's stock has risen by 50%, primarily because of aggressive marketing and the tremendous expectations for sildenafil.3 New prescriptions have increased almost exponentially—from 546 in the week ending April 3, to 269 842 in the week ending May 1.3 Urologists and nonurologists alike have been swamped with requests for the drug. The associated media frenzy has been fuelled by endorsements from prominent individuals. Such reports stoke the already intense public demand for information about and prescriptions for sildenafil. In the midst of these developments, it is crucial to recognise and deal with the potential problems. The most common side effects of sildenafil tablets for

Dose (mg)	Typical Usage Frequency	Time to Onset (minutes)	Duration of Effect (hours)	Notes
50	Once or twice daily	30-60	4-6	Starting dose for most patients
100	Once daily	30-60	4-6	Common for moderate ED
25	As needed	30-60	4-6	For mild ED
10	As needed	30-60	4-6	Lower dose option

ED are: Abnormal vision, such as changes in color

Side Effect	Incidence (%)	Severity	Recommendations
Headache	16-30	Mild to moderate	Usually resolves spontaneously
Flushing	10-15	Mild	Can be reduced with lower doses
Dyspepsia	10-20	Mild	Take with food to reduce symptoms
Nasal Congestion	10-20	Mild	Usually transient
Visual Disturbances	2-4	Mild to moderate	Rare, discontinue if persistent

vision (such as having a blue color tinge) andblurred

• Store sildenafil tablets in a cool, dry place away from sunlight.
• Keep medication out of reach of children and pets.
• Check expiration date before use to ensure potency.

vision The most common side effects of sildenafil oral

Related/similar drugs

Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, which breaks down cyclic GMP and enhances nitric oxide (NO) -mediated smooth muscle relaxation. In erectile dysfunction (ED), this increases blood flow to penile tissue, facilitating an erection. In pulmonary arterial hypertension (PAH), it dilates pulmonary vessels by the same mechanism, reducing pulmonary blood pressure and improving exercise capacity. Sildenafil first gained FDA approval on March 27, 1998. Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". film for ED are: Abnormal vision, such as changes

• Some men may experience minor flushing after taking sildenafil.
• If an adverse reaction occurs, stop medication and contact your doctor.
• Be aware of possible symptoms like sudden vision loss.

in color and blurred vision The most common side

Indexing Status

First, sildenafil is no panacea; not all patients with erectile dysfunction will benefit from it. Second, there is substantial risk that many patients will receive little or no evaluation before treatment; the potential for ill-informed and inappropriate prescribing is high.4 Third, sildenafil is not an aphrodisiac,3,4 nor does it increase sexual desire or libido.1–4 The drug has the potential for abuse by thrill-seekers. Fourth, the known side-effects may not be transient, as current data suggest. Sildenafil may also have other, as-yet-unknown, adverse effects that will become evident only over time. In the first few weeks after sildenafil's release, physicians' only information source was the package insert.2 Goldstein's study1 supplied data that physicians should use to make informed decisions in the work-up and treatment of patients with erectile dysfunction.

How were the studies combined?

Physicians who prescribe sildenafil should do so only after a comprehensive work-up (history and physical sildenafil 20 mg prescription examination, with diagnostic tests if indicated) has been completed. Oral sildenafil in the treatment of erectile dysfunction Research Question: Research Question: Funding: Funding: Year Study Began: Year Study Began: Year Study Published: Year Study Published: Study Location: Study Location: Who Was Studied: Who Was Studied: Who Was Excluded: Who Was Excluded: Patients: Patients: Study Overview: Study Overview: Study Interventions: Study Interventions: Follow-up: Follow-up: Endpoints: Endpoints: Criticism and Limitations: Criticism and Limitations: Other Relevant Studies and Information: Other Relevant Studies and Information: Summary and Implications: Summary and Implications: References References Other Relevant Studies and Information: Other Relevant Studies and Information: This chapter summarizes the results of a landmark trial comparing different doses of oral sildenafil versus placebo to treat erectile dysfunction. Patients received either an identical placebo or 25- mg, 50-mg, or 100-mg tablets of sildenafil to be taken approximately one hour before planned sexual activity (but not more than once daily) for 24 weeks. Higher doses of sildenafil resulted in higher mean score for frequency of penetration and maintenance of erection, which were also consistently better than placebo. The most common side effects were headaches, flushing, dyspepsia, rhinitis, and visual disturbances.

Institutional access

This study established sildenafil as an effective, reasonably well-tolerated treatment for men with erectile dysfunction of varying etiologies. Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways: Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account. Choose this option to get remote access when outside your institution. effects of sildenafil tablets/ oral suspension, and injection for PAH are: Sildenafil can cause the following serious side effects.

Why is this medication prescribed?

Shibboleth/Open Athens technology is used to provide single sign-on between your institution's website and Oxford Academic. Select your institution from the list provided, which will take you to your institution's website to sign in. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account. Following successful sign in, you will be returned to Oxford Academic.

Marketing and sales

If your institution is not listed or you cannot sign in to your institution's website, please contact your librarian or administrator. Enter your library card number to sign in. If you cannot sign in, please contact your librarian. Society member access to a journal is achieved in one of the following ways: Many societies offer single sign-on between the society website and Oxford Academic. If you see "Sign in through society site" in the sign in pane within a journal: When on the society site, please use the credentials provided by that society.

Revatio Tablets

If you do not have a society account or have forgotten your username or password, please contact your society. Some societies 200mg sildenafil citrate use Oxford Academic personal accounts to provide access to their members. A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions. Click the account icon in the top right to: View your signed in personal account and access account management features. View the institutional accounts that are providing access.