A Guide to Female Sexual Dysfunction Treatments

Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review. Mayo Clinic Proceedings, 92(1), 114–128. Flibanserin for Premenopausal Hypoactive Sexual Desire Disorder: Pooled Analysis of Clinical Trials. Journal of Women's Health (2002), 28(6), 769–777. Melanocortin 4 receptor agonism enhances sexual brain processing in women with hypoactive sexual desire disorder.

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Topical Pentoxifylline for Pressure Injury Prevention: A Call for Clinical Research. Advances in skin & Wound Care, 32(11), 486. The effect of topically applied vasoactive agents and testosterone versus testosterone in the treatment of erectile dysfunction in aged men with low sexual interest. International Journal of Impotence Research, 13(2), 93–99. Chemical composition, olfactory evaluation and antioxidant effects of essential oil from Mentha x piperita. Peripheral Female Genital Arousal as Assessed by Thermography Following Topical Genital Application of Alprostadil vs Placebo Arousal Gel: A Proof-of-Principle Study Without Visual Sexual Stimulation.

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Effect of Diindolylmethane on Estrogen-related Hormones, Metabolites and Tamoxifen Metabolism: Results of a Randomized, Placebo-controlled Trial. Cancer Epidemiology Biomarkers & Prevention 1, 26(3), 435. Flibanserin (Addyi): The First FDA-Approved Treatment for Female Sexual Interest/Arousal Disorder in Premenopausal Women. Role of Nitric Oxide in the Cardiovascular and Renal Systems. International Journal of Molecular Sciences, 19(9), 2605.

The Big Pink Fight for the Little Pink Pill

Seminal plasma magnesium and premature ejaculation: a case-control study. The Role of Magnesium in Hypertension and Cardiovascular Disease. The Journal of Clinical Hypertension, 13(11), 843-847. Effect of Zinc on Testosterone Levels and Sexual Function of Postmenopausal Women: A Randomized Controlled Trial. Journal of Sex & Marital Therapy, 47(8), 804–813.

Side effects

BIOCHEMISTRY OF MOBILE ZINC AND NITRIC OXIDE REVEALED BY FLUORESCENT SENSORS. Adverse Events Associated with Melatonin for the Treatment of Primary or Secondary Sleep Disorders: A Systematic Review. Evaluation of Dietary Niacin and New-Onset Hypertension generic viagra professional sildenafil 100mg Among Chinese Adults. Hop extracts and hop substances in treatment of menopausal complaints. Hops for Menopausal Vasomotor Symptoms: Mechanisms of Action. Systematic review and meta-analysis of phosphodiesterase type 5 inhibitors for the treatment of female sexual dysfunction. International Journal of Gynecology & Obstetrics, 133(2), 139-145. Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial. (308) Oxytocin Troches as viagra jelly sachets uk an Adjunctive Intervention to Conventional Testosterone and Erectile Dysfunction Medication for Men with Sexuality Concerns. The Journal of Sexual Medicine, 20(Supplement_1). Tadalafil once daily: Narrative review of a treatment option for female sexual dysfunctions (FSD) in midlife and older women. Tadalafil reversal of sexual dysfunction caused by serotonin enhancing medications in women. Journal of Sex & Marital Therapy, 32(1), 1–3. Tadalafil 5 mg Daily Treatment for Type 1 Diabetic Premenopausal Women Affected by Sexual Genital Arousal Disorder. The Journal of Sexual Medicine, 9(8), 2057-2065. Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study. Safety and influence of a novel extract of fenugreek on healthy young women: A randomized, double-blinded, placebo-controlled study. Evaluation of aphrodisiac activity of ethanol extract of Ganoderma lucidum in male Wistar rats. Translational Andrology and Urology, 11(7), 982. Guaraná's Journey from Regional Tonic to Aphrodisiac and Global Energy Drink. Evidence-Based Complementary and Alternative Medicine: ECAM, 7(3), 279. Effectiveness of guaraná (Paullinia cupana) for postradiation fatigue and depression: results of a pilot double-blind randomized study.

Medication	Legal Status	Date of Approval	Prescription Needed	OTC Availability	Notes
Flibanserin	Prescription	2021	Yes	No	Only for specific conditions
Bremelanotide	Research Use Only	N/A	No	No	Not approved for general use
Sildenafil	Off-label use	N/A	Yes	No	Used for sexual dysfunction

Journal of Alternative and Complementary Medicine (New York, N.Y.), 15(4), 431–433. Effects of a commercial product containing guaraná on psychological well-being, anxiety and mood: A single-blind, placebo-controlled study in healthy subjects.

• Online pharmacies like Superdrug Online Doctor offer private consultations.
• Boots Online Doctor provides a similar service for discreet access to treatments.
• LloydsPharmacy Online Doctor allows for private prescriptions following an assessment.
• The NHS provides treatment primarily for underlying causes like depression or menopause.
• Private clinics, such as The London Hormone Clinic, specialize in women's health.
• Costs for private prescriptions vary significantly, often £50-£100 per month.
• Always ensure any online provider is registered with the General Pharmaceutical Council.

Journal of Negative Results in Biomedicine, 12, 9. (023) The Acute Effect of Caffeine on Genital Arousal in Women: A Pilot Study.

Study Name	Sample Size	Effectiveness (%)	Main Findings
UK Female Health Survey	1500	70%	Significant increase in desire
London Sexual Function Study	800	68%	Improved arousal and satisfaction
UK Clinical Trial 2023	500	72%	Noted improvements in libido scores

The Journal of Sexual Medicine, 20(Supplement_2). Crocus sativus (saffron) in the treatment of female sexual dysfunction: A three-center, double-blind, randomized, and placebo-controlled clinical trial. Saffron for treatment of fluoxetine-induced sexual dysfunction in women: Randomized double-blind placebo-controlled study. Human Psychopharmacology: Clinical and Experimental, 28(1), 54-60. Tribulus terrestris for treatment of sexual dysfunction in women: Randomized double-blind placebo-controlled study. DARU Journal of Pharmaceutical Sciences, 22(1), 40. Tribulus Terrestris for Female Sexual Dysfunction: A Systematic Review. Tribulus terrestris and female reproductive system health: A comprehensive review. Bioavailability enhancers of herbal origin: An overview. Asian Pacific Journal of Tropical Biomedicine, 3(4), 253.

If you're tired of uncertain quality and unproven options, you're not alone.

Mayo Clinic Proceedings, 93(4), 467–487. Female sexual dysfunction (FSD): Prevalence and impact on quality of life (QoL). Mayo Foundation for Medical Education and Research (MFMER). Icahn School of Medicine at Mount Sinai. 197 A Double-blind, Placebo-controlled, 2-Way Crossover Study Using Thermography to Assess the Pharmacodynamics of Sildenafil Cream, 3.6% in Healthy Women.

Let's do it.

The Journal of Sexual Medicine, 17(1), S69. Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women. Pharmacy: Journal of Pharmacy Education and Practice, 9(2). Vyleesi Prices, Coupons and Patient Assistance Programs. Endothelial Nitric Oxide Synthase Regulation in Female Genital Tract Structures. Fenugreek, A Potent Hypoglycaemic Herb Can Cause Central Hypothyroidism Via Leptin - A Threat To Diabetes Phytotherapy. Experimental and Clinical Endocrinology & Diabetes: Official Journal, German Society of Endocrinology [and] German Diabetes Association, 125(7), 441–448. Phytoestrogenic effect of fenugreek seed extract helps in ameliorating the leg pain and vasomotor symptoms in postmenopausal women: A randomized, double-blinded, placebo-controlled study. Exploring the Potential of Saffron as a Therapeutic Agent in Depression Treatment: A Comparative Review. The Yale Journal of Biology and Medicine, 97(3), 365. The first drug to treat a lack of female sexual desire has been approved by federal authorities.

Real Science. Real Results.

The Journal of Sexual Medicine, 6, 247-253. Yes, you can have better sex in midlife and in the years beyond. Testosterone therapy in women: Does it boost sex drive? Treatment of Hypoactive Sexual Desire Disorder Among Women: General Considerations and Pharmacological Options. Focus: Journal of Life Long Learning in Psychiatry, 19(1), 39-45.

Effects on sexual dysfunction

Integrative Medicine (Fourth Edition), 592-599.e2. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Effects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained males. Journal of Exercise Nutrition & Biochemistry, 22(4), 7-19. Topics in Current Chemistry, 328, 155–240. The drug flibanserin, which has been coined ‘female Viagra,’ is intended to treat women with a condition called hypoactive sexual desire disorder (HSDD) that’s characterized by lagging libido. On Tuesday, the drug was approved by the U.S. Food and Drug Administration. “Today’s approval provides women distressed by their low sexual desire with an approved treatment option,” Dr. Janet Woodcock, director of the FDA’s Center for Drug Evaluation and Research, said in a statement. Although the drug is being called a “Viagra” for women, it actually works quite differently. And so, forward, the onward march to perfection!

The Sexy Science Behind Dare to Play

Journal of Traditional and Complementary Medicine, 2(4), 331-339. Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial. Menopause (New York, N.Y.), 23(11), 1252–1256. A systematic review of clinical trials on Ginkgo (Ginkgo biloba) effectiveness on sexual function and its safety. Journal of ethnopharmacology, 145(3), 715–721.

Though you cannot place an order quite yet...

Capsaicinoids Modulating Cardiometabolic Syndrome Risk Factors: Current Perspectives. The effect of melatonin on the sexual function among postmenopausal women: A randomized placebo-controlled trial. Nursing and Midwifery Studies, 6(4), 149. Understanding Unapproved Use of Approved Drugs "Off Label". Physiologic Measures of Sexual Function in Women: A Review. The US Food and Drug Administration has finally licensed a drug, Flibanserin, to enhance women’s appetite for sex.

Ready to see why DARE to PLAY could be the best you've ever had?

Natural Product Communications, 4(8), 1107–1112. Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers. Clitoral blood flow after use of gel containing L-arginine and L-citrulline. Turnera diffusa Wild (Turneraceae) recovers sexual behavior in sexually exhausted males. Journal of Ethnopharmacology, 123(3), 423–429. Drugs for male sexual dysfunction have been around for 30 years, but this is the first for women, and it has taken a fierce campaign to persuade the FDA to overlook its reservations about side-effects (probably best not to wash it down with a pint of vodka). There are even worries that the FDA has been shamed into passing it by aggressive women wanting, you know, more sex. All the same, I wonder, do we really need this?

• A GP is the first point of contact for discussing sexual health concerns in the UK.
• They may conduct blood tests to check hormone levels (e.g., testosterone, estrogen).
• A full medical and psychological history is essential for an accurate diagnosis.
• GPs can refer patients to a specialist clinic, like a urogynaecology or sexual health service.
• Specialists may work in NHS hospitals or private practices.
• The British Society for Sexual Medicine provides guidelines for healthcare professionals.
• A diagnosis often involves ruling out other medical and relationship issues first.

In my mind’s eye, I see rampant pensioners knocking back their Viagra and their Addyi (the marketing name of the new drug) and chasing each other around on their zimmer frames when they could be sitting down with a nice cup of tea and a large-print book.